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IHC experiments to detect PEG were conducted to further examine the relationship between the administration of Jintrolong® and the development of vacuolation in the CP. As shown hinein Figure 4, no PEG staining welches detected in the brain CP hinein animals of the control group (Figures 4A–Kohlenstoff) or the 0.3 Magnesium/kg group (Figures 4D–fluor). However, positive anti-PEG was observed rein animals at 1 mg/kg (Figure 4G) and with an even stronger staining signal at 3 mg/kg (Figure 4J).

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The datasets presented hinein this study can be found hinein online repositories. The names of the repository/repositories and accession number(s) can be found in the article/Supplementary Material.

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To determine if glucose metabolism rein the brains of treated monkeys welches intact, 18F-FDG-PET welches performed in recovery animals treated with 3 Magnesium/kg/week during the 148-week recovery period.

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To determine whether the Jintrolong®-dependent vacuolation observed in CP resulted rein the alteration of cellular ultrastructure and function of the CP, brain tissue was collected for TEM at the Am ende gelegen necropsy following the belastung dosing and at the recovery necropsy.

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